{
  "id": 3013611,
  "title": "Epithelial and γδ T cell CD47 have complementary yet distinct roles in regulating γδ intraepithelial lymphocyte migration",
  "url": "https://urgent.news/2026/08/24/epithelial-and-t-cell-cd47-have-complementary-yet-distinct-roles-in",
  "topic": "science",
  "section": "Science",
  "published": "2026-08-24T00:00:00.000Z",
  "source": {
    "name": "bioRxiv",
    "slug": "biorxiv",
    "url": "https://www.biorxiv.org/content/10.64898/2026.08.19.745759v1?rss=1"
  },
  "original_language": "en",
  "account": "Intraepithelial lymphocytes, known as {gamma}{delta} IELs, actively patrol the intestinal epithelium to defend against pathogens. While the mechanisms behind their migration between enterocytes are not fully understood, researchers have discovered that CD47 plays a crucial role in this process. In a study examining the impact of CD47 deletion on {gamma}{delta} IELs, they found that its expression does not affect the composition of these cells. Intravital imaging revealed a dual role for CD47, with epithelial cells restricting {gamma}{delta} IEL motility and {gamma}{delta} T-cells promoting their migration. Further analysis showed that both CD47 and CD18 contribute to {gamma}{delta} IEL surveillance, with CD47 exerting its influence independently of CD18.",
  "summary": "Intraepithelial lymphocytes expressing the {gamma}{delta} T cell receptor ({gamma}{delta} IEL) continuously survey the intestinal epithelium to promote mucosal host defense. Although {gamma}{delta} IELs migrate in and out of the lateral intercellular space (LIS) between adjacent enterocytes, the molecular mechanisms governing their migratory behavior are incompletely understood. Based on the…",
  "key_points": [],
  "editors_take": null,
  "illustration": null,
  "coverage": {
    "outlets": 1,
    "also_reported_by": []
  },
  "ai_generated": true,
  "disclaimer": "Summaries, key points and the editor’s take are written by software from other outlets’ reporting and may contain errors — always check the linked original."
}