{
  "id": 2969319,
  "title": "Phase-dependent closed-loop intersectional short-pulse stimulation reduces seizure duration: From computational modeling to clinical application",
  "url": "https://urgent.news/2026/08/23/phase-dependent-closed-loop-intersectional-short-pulse-stimulation",
  "topic": "science",
  "section": "Science",
  "published": "2026-08-23T00:00:00.000Z",
  "source": {
    "name": "bioRxiv",
    "slug": "biorxiv",
    "url": "https://www.biorxiv.org/content/10.64898/2026.08.19.745828v1?rss=1"
  },
  "original_language": "en",
  "account": "Drug-resistant epilepsy affects one-third of patients, despite optimal therapy. Intersectional short-pulse (ISP) stimulation, a novel transcranial electrical technique, delivers precise, targeted modulation of aberrant brain activity. To understand the link between stimulation phase and seizure attenuation, researchers combined computational modeling with measurements in a rat epilepsy model and human patients.\n\nSimulations of epileptiform networks demonstrated that ISP significantly reduced seizure duration, with efficacy heavily reliant on the phase of delivery. Optimal stimulation during the rising phase and around seizure oscillation peaks (~45-90 degrees) led to the largest seizure length reduction. In rats, ISP decreased seizure duration by 42.4% and shortened generalized seizure segments by 58.3%. Human trials showed a 60.9% reduction in seizure length compared to control seizures.\n\nPhase dependence was consistent across models and species, with a prominent efficacy window during the rising-to-peak portion of the ictal oscillation. Additionally, model-specific secondary windows were identified. These findings indicate that phase-targeted ISP can substantially shorten seizures, supporting phase-resolved stimulation as a precision-neuromodulation approach for epilepsy.",
  "summary": "Drug-resistant epilepsy affects one-third of patients with persistent seizures despite optimal therapy. Intersectional short-pulse (ISP) stimulation is a novel transcranial electrical stimulation technique designed to deliver temporally precise, spatially targeted modulation of pathological brain activity. Here, we combined computational modeling with measurements in a rat epilepsy model and in…",
  "key_points": [],
  "editors_take": null,
  "illustration": null,
  "coverage": {
    "outlets": 1,
    "also_reported_by": []
  },
  "ai_generated": true,
  "disclaimer": "Summaries, key points and the editor’s take are written by software from other outlets’ reporting and may contain errors — always check the linked original."
}