{
  "id": 293649,
  "title": "Host CD59 potentiates the type III secretion system in Yersinia pseudotuberculosis",
  "url": "https://urgent.news/2026/08/08/host-cd59-potentiates-the-type-iii-secretion-system-in-yersinia",
  "topic": "science",
  "section": "Science",
  "published": "2026-08-08T00:00:00.000Z",
  "source": {
    "name": "Scientific Reports",
    "slug": "scientific-reports",
    "url": "https://www.nature.com/articles/s41598-026-65480-x"
  },
  "original_language": "en",
  "account": "The research explores the role of host protein CD59 in facilitating the type III secretion system (T3SS) of Yersinia pseudotuberculosis (Yptb). Previous studies have shown that CD59 is crucial for the translocation of Yptb T3SS effectors into the host cytosol. In this study, the researchers investigated how CD59 affects T3SS function and membrane dynamics. They found that both low and high levels of CD59 reduced T3SS pore formation and Yop translocation into host cells. The depletion of CD59 also interfered with the rearrangement of lipid rafts and altered phosphatidylcholine levels, suggesting that CD59 modulates lipid microdomain dynamics. This work identifies CD59 as a key host factor supporting plasma membrane dynamics necessary for efficient T3SS translocon function.",
  "summary": "Scientific Reports, Published online: 08 August 2026; doi:10.1038/s41598-026-65480-x Host CD59 potentiates the type III secretion system in Yersinia pseudotuberculosis",
  "key_points": [
    "Host protein CD59 potentiates type III secretion system in Yersinia pseudotuberculosis",
    "Low and high CD59 levels reduce T3SS pore formation and Yop translocation",
    "CD59 modulates lipid rafts and phosphatidylcholine levels during T3SS translocon function"
  ],
  "editors_take": "This finding that CD59 supports plasma membrane dynamics for efficient type III secretion system translocon function suggests that manipulating CD59 levels could be a strategy to inhibit Yersinia pseudotuberculosis infection.",
  "illustration": "https://urgent.news/ill/293649.png",
  "coverage": {
    "outlets": 1,
    "also_reported_by": []
  },
  "ai_generated": true,
  "disclaimer": "Summaries, key points and the editor’s take are written by software from other outlets’ reporting and may contain errors — always check the linked original."
}