{
  "id": 28295,
  "title": "Expanding the Developmental Origins of Health and Disease beyond maternal behaviors",
  "url": "https://urgent.news/2026/07/30/expanding-the-developmental-origins-of-health-and-disease-beyond",
  "topic": "health",
  "section": "Health & Medicine",
  "published": "2026-07-30T14:00:00.000Z",
  "source": {
    "name": "PLOS Medicine",
    "slug": "plos-medicine",
    "url": "https://journals.plos.org/plosmedicine/article?id=10.1371/journal.pmed.1005208"
  },
  "original_language": "en",
  "account": "For decades, the Developmental Origins of Health and Disease (DOHaD) concept has focused on how early-life exposures, particularly maternal behaviors during pregnancy, influence child health. However, a recent study published in PLOS Medicine suggests that socioeconomic disadvantage may play a more significant role than previously thought.\n\nLed by Sharp and colleagues, the study analyzed data from four birth cohorts spanning two decades, examining maternal and co-parent behaviors such as smoking, alcohol consumption, caffeine intake, and socioeconomic position in relation to over 70 child health outcomes. By employing various methods including meta-analyses, mendelian randomization, and genetic risk scores, the researchers aimed to establish stronger causal inferences regarding intrauterine effects from shared familial and wider socioeconomic influences.\n\nThe findings indicate that, while maternal smoking remains associated with certain birth and later-life health outcomes, its impact is largely diminished after accounting for genetic factors. In contrast, socioeconomic position showed consistent associations across multiple outcomes, suggesting that broader social circumstances may exert a greater influence on child health than previous studies had acknowledged.\n\nThe authors commend the study for its comprehensive approach and utilization of multiple birth cohorts, which allows for a more robust assessment of the relative contributions of modifiable behaviors and socioeconomic circumstances to child health. However, they highlight a limitation in the study's representation of ethnic diversity, given the persistent ethnic inequality in pregnancy outcomes in the UK.\n\nThe study challenges the traditional emphasis on modifying maternal behaviors during pregnancy as the primary means to improve child health. Instead, it aligns with the growing body of evidence highlighting the social determinants of health, showing that individual behaviors are deeply rooted in the social and economic conditions in which people live. For instance, persistent childhood poverty is linked to increased mortality in early adulthood, and unconditional cash transfers during pregnancy have been shown to improve infant outcomes.\n\nThe findings underscore the need for a shift in focus from maternal behaviors alone to addressing the social and structural drivers of child health. This includes implementing upstream interventions such as cash transfers, which have demonstrable benefits for early-life health. By recognizing that child health is influenced by a complex interplay of factors beyond maternal actions, the DOHaD paradigm can better inform policies and interventions aimed at creating a more equitable and healthier future for all children.",
  "summary": "by Alice Rhiannon Lee, Daniel B. Hawcutt, Jennifer K. Quint, Ian P. Sinha Developmental Origins of Health and Disease (DOHaD) research has long emphasized maternal pregnancy behaviors as key determinants of child health. New evidence recently published in PLOS Medicine suggests the greatest opportunities to improve child health may lie in tackling socioeconomic disadvantage rather than maternal…",
  "key_points": [],
  "editors_take": null,
  "illustration": null,
  "coverage": {
    "outlets": 1,
    "also_reported_by": []
  },
  "ai_generated": true,
  "disclaimer": "Summaries, key points and the editor’s take are written by software from other outlets’ reporting and may contain errors — always check the linked original."
}