{
  "id": 269767,
  "title": "A general mathematical framework for modelling subnetworks of the nuclear auxin pathway",
  "url": "https://urgent.news/2026/08/07/a-general-mathematical-framework-for-modelling-subnetworks-of-the",
  "topic": "world",
  "section": "World",
  "published": "2026-08-07T00:00:00.000Z",
  "source": {
    "name": "bioRxiv",
    "slug": "biorxiv",
    "url": "https://www.biorxiv.org/content/10.64898/2026.08.06.742982v1?rss=1"
  },
  "original_language": "en",
  "account": "Auxins, a group of plant hormones, play a crucial role in the functioning of various plant tissues and species. The Nuclear Auxin Pathway (NAP) is a network involving transcription factors (ARFs) and repressors (Aux/IAAs), which govern the response of individual cells to alterations in auxin concentration. This pathway is ubiquitous in land plants, with many species possessing multiple copies of each signaling component.\n\nIn this study, we introduce a general mathematical framework for modeling subnetworks of the NAP using ordinary differential equations (ODEs). This model is adaptable to any combination of transcriptional regulators, enabling the simulation of the promotion and repression of target genes. Through the application of this framework to published data, we observed that auxin treatment in Arabidopsis thaliana roots leads to distinct temporal response profiles for both target genes and the signaling components themselves.\n\nTo demonstrate the effectiveness of our modeling framework, we present examples of real and theoretical NAP subnetworks. By analyzing these networks and the effect of their dynamics on auxin-mediated transcriptional responses, we showcase the utility of our framework as a general-purpose tool for understanding the function of protein-protein and protein-DNA interactions within the NAP. This research not only highlights the complexity of signalling pathways but also opens up new avenues for advancing our understanding of the NAP.",
  "summary": "Auxins are a family of plant hormones involved in various processes across plant tissues and species. The Nuclear Auxin Pathway (NAP) consists of interacting transcription factors (ARFs) and repressors (Aux/IAAs), which govern an individual cell's response to changes in auxin concentration. These components are present in all land plants, and many species possess multiple copies of each…",
  "key_points": [
    "Introduces mathematical framework for NAP modeling using ODEs",
    "Adaptable to any combination of transcriptional regulators",
    "Demonstrates framework with real and theoretical NAP subnetworks"
  ],
  "editors_take": null,
  "illustration": null,
  "coverage": {
    "outlets": 1,
    "also_reported_by": []
  },
  "ai_generated": true,
  "disclaimer": "Summaries, key points and the editor’s take are written by software from other outlets’ reporting and may contain errors — always check the linked original."
}