{
  "id": 2600913,
  "title": "AI decodes DNA initiator sequence found in about 60% of human genes",
  "url": "https://urgent.news/2026/08/22/ai-decodes-dna-initiator-sequence-found-in-about-60-of-human-genes",
  "topic": "science",
  "section": "Science",
  "published": "2026-08-22T15:40:01.000Z",
  "source": {
    "name": "Phys.org",
    "slug": "phys-org",
    "url": "https://phys.org/news/2026-08-ai-decodes-dna-sequence-human.html"
  },
  "original_language": "en",
  "account": "In a study led by UC San Diego professor James T. Kadonaga, researchers have used high-throughput DNA sequencing and artificial intelligence to decode a crucial DNA sequence known as the initiator. This sequence is found in approximately 60% of human genes and plays a vital role in the activation of tens of thousands of genes, which are essential for healthy development and function. By analyzing 500,000 different versions of the initiator, the researchers developed an AI model that successfully predicted the presence or absence of the initiator in human genes. This breakthrough will enable researchers to better understand the effects of DNA mutations linked to disorders and design synthetic promoters with customized functions. The study, titled \"Machine learning analysis of the human initiator region reveals key features of different types of core promoters,\" was published in Genes and Development.",
  "summary": "Precise activation of tens of thousands of genes is critical for healthy development and growth. Specialized segments of our DNA are responsible for carefully orchestrating genetic sequences that result in the production of enzymes, hormones, proteins and other crucial components underlying cell structure and function. But if these genes are not correctly activated, cells can stop functioning or…",
  "key_points": [
    "UC San Diego researchers use AI to decode DNA initiator sequence.",
    "Initiator found in 60% of human genes, crucial for gene activation.",
    "Study published in Genes and Development, aids understanding of DNA mutations."
  ],
  "editors_take": null,
  "illustration": null,
  "coverage": {
    "outlets": 1,
    "also_reported_by": []
  },
  "ai_generated": true,
  "disclaimer": "Summaries, key points and the editor’s take are written by software from other outlets’ reporting and may contain errors — always check the linked original."
}