{
  "id": 2369262,
  "title": "Scarless conditional sgRNAs via endogenous mascRNA processing enable rapid and temporally controlled genome editing",
  "url": "https://urgent.news/2026/08/21/scarless-conditional-sgrnas-via-endogenous-mascrna-processing-enable",
  "topic": "science",
  "section": "Science",
  "published": "2026-08-21T00:00:00.000Z",
  "source": {
    "name": "bioRxiv",
    "slug": "biorxiv",
    "url": "https://www.biorxiv.org/content/10.64898/2026.08.20.745814v1?rss=1"
  },
  "original_language": "en",
  "account": null,
  "summary": "Precise temporal control of gene editing is essential for studying dynamic biological processes, interrogating essential gene function, and improving the interpretability of pooled perturbation screens. Cre-dependent single guide RNA (sgRNA) switches provide temporal regulation by coupling guide activation to site-specific recombination, but existing designs retain a loxP-derived 5' sequence…",
  "key_points": [],
  "editors_take": null,
  "illustration": null,
  "coverage": {
    "outlets": 1,
    "also_reported_by": []
  },
  "ai_generated": true,
  "disclaimer": "Summaries, key points and the editor’s take are written by software from other outlets’ reporting and may contain errors — always check the linked original."
}