{
  "id": 236206,
  "title": "A One-Two Punch: New Drug Overfeeds—Then Starves—Cancer Cells",
  "url": "https://urgent.news/2026/08/06/a-one-two-punch-new-drug-overfeeds-then-starves-cancer-cells",
  "topic": "science",
  "section": "Science",
  "published": "2026-08-06T20:00:00.000Z",
  "source": {
    "name": "Nautilus",
    "slug": "nautilus",
    "url": "https://nautil.us/a-one-two-punch-new-drug-overfeeds-then-starves-cancer-cells-1283471/"
  },
  "original_language": "en",
  "account": "A novel drug, developed by researchers at the University of Texas, targets cancer cells using a two-step process that overfeeds them with glucose before starving them of energy. This unique approach, described in a paper published in Nature Chemical Biology, could potentially be applied to treat other diseases as well. The drug works by activating the enzyme glycolysis, causing cancer cells to deplete their glucose reserves. Simultaneously, the drug inhibits the breakdown of fatty acids, preventing the cells from replenishing their energy stores. This dual-action destroys the cells, effectively 'starving' them of the resources they need to survive and grow. The innovative compound, which acts as a smaller, more accessible alternative to antibody-drug conjugates (ADCs), is easier to manufacture and can target proteins inside cells, not just those on the surface. Study co-author Ken Hsu likened this new drug to a fully-chemical counterpart to ADCs, highlighting its potential advantages in terms of production and targeting capabilities. While further research and testing are necessary, the researchers are optimistic about the drug's ability to 'strike a one-two punch' against cancer cells. They believe their approach could be adapted for use in other disease treatments, offering a promising avenue for future medical advancements.",
  "summary": "The two-step process could help fight other diseases as well The post A One-Two Punch: New Drug Overfeeds—Then Starves—Cancer Cells appeared first on Nautilus .",
  "key_points": [
    "Novel drug targets cancer cells via two-step glucose process",
    "Overfeeds cells with glucose, then inhibits fatty acid breakdown",
    "Potential alternative to antibody-drug conjugates with manufacturing advantages"
  ],
  "editors_take": "This new drug's dual-action approach to targeting cancer cells positions it as a potentially more effective and adaptable treatment option, with advantages in production and targeting capabilities over existing therapies.",
  "illustration": null,
  "coverage": {
    "outlets": 1,
    "also_reported_by": []
  },
  "ai_generated": true,
  "disclaimer": "Summaries, key points and the editor’s take are written by software from other outlets’ reporting and may contain errors — always check the linked original."
}