{
  "id": 2256146,
  "title": "Discovery and optimization of the next generation of cell active Protein Kinase Novel 3 (PKN3) inhibitors",
  "url": "https://urgent.news/2026/08/20/discovery-and-optimization-of-the-next-generation-of-cell-active",
  "topic": "culture",
  "section": "Culture",
  "published": "2026-08-20T00:00:00.000Z",
  "source": {
    "name": "bioRxiv",
    "slug": "biorxiv",
    "url": "https://www.biorxiv.org/content/10.64898/2026.08.20.745975v1?rss=1"
  },
  "original_language": "en",
  "account": null,
  "summary": "Protein Kinase Novel 3 (PKN3) understudied kinase with a diverse array of biological functions that are yet to be fully defined. Here, we report the design and development of a novel advanced functional chemical tool inhibitor for PKN3. A pyridyl imidazole series has been synthesized and evaluated against PKN3 in vitro and in cells. These efforts led to the discovery of 6e (URS03-06), a…",
  "key_points": [],
  "editors_take": null,
  "illustration": null,
  "coverage": {
    "outlets": 1,
    "also_reported_by": []
  },
  "ai_generated": true,
  "disclaimer": "Summaries, key points and the editor’s take are written by software from other outlets’ reporting and may contain errors — always check the linked original."
}