{
  "id": 206371,
  "title": "Trajectory Uncertainty Framework (TUF): A Modular Framework for Identifying Transitional and Branch-Point Cell States in Single-Cell Trajectory Analysis",
  "url": "https://urgent.news/2026/08/05/trajectory-uncertainty-framework-tuf-a-modular-framework-for",
  "topic": "ai",
  "section": "AI",
  "published": "2026-08-05T00:00:00.000Z",
  "source": {
    "name": "bioRxiv",
    "slug": "biorxiv",
    "url": "https://www.biorxiv.org/content/10.64898/2026.07.31.742012v1?rss=1"
  },
  "original_language": "en",
  "account": null,
  "summary": "Single-cell trajectory inference methods assign pseudotime coordinates but provide limited information on assignment uncertainty, especially at transitional states and branch points. We introduce the Trajectory Uncertainty Framework (TUF), a modular, downstream approach that defines a 2D uncertainty coordinate system for single-cell data. TUF decomposes local uncertainty into the Temporal Entropy…",
  "key_points": [],
  "editors_take": null,
  "illustration": null,
  "coverage": {
    "outlets": 1,
    "also_reported_by": []
  },
  "ai_generated": true,
  "disclaimer": "Summaries, key points and the editor’s take are written by software from other outlets’ reporting and may contain errors — always check the linked original."
}