{
  "id": 19854148,
  "title": "Neuronal Aralar/AGC1 deficiency impairs social behavior through dopaminergic and redox dysfunction and is rescued by β-hydroxybutyrate",
  "url": "https://urgent.news/2026/11/13/neuronal-aralar-agc1-deficiency-impairs-social-behavior-through",
  "topic": "science",
  "section": "Science",
  "published": "2026-11-13T00:00:00.000Z",
  "source": {
    "name": "bioRxiv",
    "slug": "biorxiv",
    "url": "https://www.biorxiv.org/content/10.64898/2026.11.12.766132v1?rss=1"
  },
  "original_language": "en",
  "account": null,
  "summary": "Background: Pathogenic variants in SLC25A12/AGC1 (Aralar) have been linked to autism spectrum disorder (ASD), yet the mechanisms connecting neuronal metabolic dysfunction to altered social behavior remain poorly understood. Aralar is a key component of the malate-aspartate shuttle, supporting neuronal oxidative metabolism and lactate utilization. Here, we investigated the consequences of…",
  "key_points": [],
  "editors_take": null,
  "illustration": null,
  "coverage": {
    "outlets": 1,
    "also_reported_by": []
  },
  "ai_generated": true,
  "disclaimer": "Summaries, key points and the editor’s take are written by software from other outlets’ reporting and may contain errors — always check the linked original."
}