{
  "id": 19854136,
  "title": "An oxidative mutational signature in normal tissues of a monoallelic MUTYH carrier",
  "url": "https://urgent.news/2026/11/13/an-oxidative-mutational-signature-in-normal-tissues-of-a-monoallelic",
  "topic": "science",
  "section": "Science",
  "published": "2026-11-13T00:00:00.000Z",
  "source": {
    "name": "bioRxiv",
    "slug": "biorxiv",
    "url": "https://www.biorxiv.org/content/10.64898/2026.11.12.766009v1?rss=1"
  },
  "original_language": "en",
  "account": null,
  "summary": "Biallelic loss of MUTYH causes MUTYH-associated polyposis (OMIM: 608456), characterized by the oxidative base-excision-repair mutational signature SBS18, but whether the roughly 1 in 100 individuals who carry a single pathogenic MUTYH allele acquire a mutational phenotype in normal tissue is unknown. Analysis of multi-tissue sequencing of 25 donors from the Somatic Mosaicism across Human Tissues…",
  "key_points": [],
  "editors_take": null,
  "illustration": null,
  "coverage": {
    "outlets": 1,
    "also_reported_by": []
  },
  "ai_generated": true,
  "disclaimer": "Summaries, key points and the editor’s take are written by software from other outlets’ reporting and may contain errors — always check the linked original."
}