{
  "id": 19854135,
  "title": "DeepRNAi: Predicting on- and off-target siRNA activity and establishing a benchmark",
  "url": "https://urgent.news/2026/11/13/deeprnai-predicting-on-and-off-target-sirna-activity-and-establishing",
  "topic": "science",
  "section": "Science",
  "published": "2026-11-13T00:00:00.000Z",
  "source": {
    "name": "bioRxiv",
    "slug": "biorxiv",
    "url": "https://www.biorxiv.org/content/10.64898/2026.11.12.766311v1?rss=1"
  },
  "original_language": "en",
  "account": null,
  "summary": "Small interfering RNAs (siRNAs) silence target genes through RISC-mediated hybridization and cleavage, but can silence unintended transcripts and cause toxicity or complicate regulatory approval. In drug development, empirical assessment by qPCR and RNA-seq is slow, forces early candidate prioritization, and is limited by available species- and genome-appropriate cell models. While extensive…",
  "key_points": [],
  "editors_take": null,
  "illustration": null,
  "coverage": {
    "outlets": 1,
    "also_reported_by": []
  },
  "ai_generated": true,
  "disclaimer": "Summaries, key points and the editor’s take are written by software from other outlets’ reporting and may contain errors — always check the linked original."
}