{
  "id": 19726506,
  "title": "HPV Oncogenes rewire DNA crosslink repair to create a PRIMPOL-dependent therapeutic vulnerability",
  "url": "https://urgent.news/2026/11/12/hpv-oncogenes-rewire-dna-crosslink-repair-to-create-a-primpol",
  "topic": "science",
  "section": "Science",
  "published": "2026-11-12T00:00:00.000Z",
  "source": {
    "name": "bioRxiv",
    "slug": "biorxiv",
    "url": "https://www.biorxiv.org/content/10.64898/2026.11.10.765685v1?rss=1"
  },
  "original_language": "en",
  "account": null,
  "summary": "Cisplatin-based chemoradiation is the standard of care for both HPV-negative (HPV-) and HPV-positive (HPV+) head and neck squamous cell carcinoma (HNSCC), even though patients with HPV+ tumors have better treatment responses and a better prognosis. Understanding how HPV status shapes this response could guide alternative strategies that lower long-term toxicity. Using genome-wide CRISPR screens,…",
  "key_points": [],
  "editors_take": null,
  "illustration": null,
  "coverage": {
    "outlets": 1,
    "also_reported_by": []
  },
  "ai_generated": true,
  "disclaimer": "Summaries, key points and the editor’s take are written by software from other outlets’ reporting and may contain errors — always check the linked original."
}