{
  "id": 19726503,
  "title": "Lipid-Driven NRF2 Preconditioning Links Estrogen Deprivation to Hepatic Resilience Against Acetaminophen Injury",
  "url": "https://urgent.news/2026/11/12/lipid-driven-nrf2-preconditioning-links-estrogen-deprivation-to",
  "topic": "science",
  "section": "Science",
  "published": "2026-11-12T00:00:00.000Z",
  "source": {
    "name": "bioRxiv",
    "slug": "biorxiv",
    "url": "https://www.biorxiv.org/content/10.64898/2026.11.10.765604v1?rss=1"
  },
  "original_language": "en",
  "account": null,
  "summary": "Background & Aims: Menopause is associated with a sustained decline in estrogen signaling that profoundly alters hepatic lipid metabolism; however, its impact on the liver response to xenobiotic stress remains poorly understood. Given that acetaminophen (APAP) overdose is a leading cause of drug-induced acute liver failure (DILI) and that sex and age influence susceptibility to hepatotoxicity, we…",
  "key_points": [],
  "editors_take": null,
  "illustration": null,
  "coverage": {
    "outlets": 1,
    "also_reported_by": []
  },
  "ai_generated": true,
  "disclaimer": "Summaries, key points and the editor’s take are written by software from other outlets’ reporting and may contain errors — always check the linked original."
}