{
  "id": 19703146,
  "title": "High Frequency of Drug-Impacting Gene Variants Found in All of Us Cohort",
  "url": "https://urgent.news/2026/11/12/high-frequency-of-drug-impacting-gene-variants-found-in-all-of-us",
  "topic": "health",
  "section": "Health & Medicine",
  "published": "2026-11-12T20:17:04.000Z",
  "source": {
    "name": "GEN Biotechnology",
    "slug": "gen-biotechnology",
    "url": "https://www.genengnews.com/topics/omics/high-frequency-of-drug-impacting-gene-variants-found-in-all-of-us-cohort/"
  },
  "original_language": "en",
  "account": "Researchers at the University of Pittsburgh have discovered that nearly all participants in the National Institutes of Health’s All of Us Research Program carry at least one genetic variant that influences how their bodies process medications. The study, published in Science Translational Medicine, found that a quarter of these individuals had been prescribed a drug known to be affected by their specific genetic variant. The researchers emphasize the importance of genetic testing for certain medications and suggest that electronic health record alerts could aid clinicians in determining appropriate prescriptions or dosage adjustments. Associate Professor Philip E. Empey, PharmD, PhD, who led the study, highlights that genetics could be a significant factor in medication response among many patients, underscoring the potential benefits of precision medicine. The study utilized data from the All of Us Research Program, which aims to collect data from one million diverse participants across the U.S. to improve understanding of how genetics, lifestyle, and environment impact health. By linking genetic data to medical records, the researchers determined that 24.38% of participants had received at least one medication known to interact with their genetic variant. The most common affected drugs included ondansetron (anti-nausea), ibuprofen (anti-inflammatory), omeprazole and pantoprazole (both for acid reflux), and atorvastatin (cholesterol-lowering medication). The findings shed light on the prevalence of pharmacogenomic variants and their impact on medication effectiveness and toxicity, particularly in populations previously underrepresented in genetic research.",
  "summary": "A study finds that everyone in a diverse, nearly 100,000-person sample carried at least one genetic variant that affects how their body processes medications, and a quarter of those people had been prescribed a medication that is known to be impacted by the variant they carried. The post High Frequency of Drug-Impacting Gene Variants Found in All of Us Cohort appeared first on GEN - Genetic…",
  "key_points": [],
  "editors_take": null,
  "illustration": null,
  "coverage": {
    "outlets": 1,
    "also_reported_by": []
  },
  "ai_generated": true,
  "disclaimer": "Summaries, key points and the editor’s take are written by software from other outlets’ reporting and may contain errors — always check the linked original."
}