{
  "id": 19682028,
  "title": "Combination therapy overcomes treatment resistance in breast cancer models",
  "url": "https://urgent.news/2026/11/12/combination-therapy-overcomes-treatment-resistance-in-breast-cancer",
  "topic": "health",
  "section": "Health & Medicine",
  "published": "2026-11-12T17:40:10.000Z",
  "source": {
    "name": "Medical Xpress",
    "slug": "medical-xpress",
    "url": "https://medicalxpress.com/news/2026-11-combination-therapy-treatment-resistance-breast.html"
  },
  "original_language": "en",
  "account": null,
  "summary": "Researchers at The University of Texas MD Anderson Cancer Center have developed a computational biology algorithm called TargetScore, which successfully overcame treatment resistance in preclinical models of advanced breast cancer. TargetScore evaluates networks of proteins and molecular signatures that work together inside tumor cells while under therapeutic stress, identifying potential backup routes that cancer cells use to survive despite initial targeted therapies. By targeting both PARP and SHP2 proteins simultaneously, the combination therapy significantly slowed cancer growth and improved survival in multiple preclinical models of breast cancer, particularly in cells with defects in DNA repair that had already developed resistance to therapy. This study highlights the potential of TargetScore to identify more effective drug combinations to improve patient outcomes, although further validation in clinical trials is needed.",
  "key_points": [],
  "editors_take": null,
  "illustration": null,
  "coverage": {
    "outlets": 1,
    "also_reported_by": []
  },
  "ai_generated": true,
  "disclaimer": "Summaries, key points and the editor’s take are written by software from other outlets’ reporting and may contain errors — always check the linked original."
}