{
  "id": 19656827,
  "title": "SUMOylation Regulates IRF2BP2 Nuclear Localization and Stability",
  "url": "https://urgent.news/2026/11/12/sumoylation-regulates-irf2bp2-nuclear-localization-and-stability",
  "topic": "science",
  "section": "Science",
  "published": "2026-11-12T00:00:00.000Z",
  "source": {
    "name": "bioRxiv",
    "slug": "biorxiv",
    "url": "https://www.biorxiv.org/content/10.64898/2026.11.09.765419v1?rss=1"
  },
  "original_language": "en",
  "account": null,
  "summary": "Interferon Regulatory Factor-2 Binding Protein 2 (IRF2BP2) is a transcriptional cofactor implicated in diverse biological processes. Although it functions primarily as a repressor, it can also activate gene expression. However, the mechanisms governing IRF2BP2 regulation remain poorly understood. Here, we demonstrate that IRF2BP2 interacts with UBE2I, the SUMO E2 ligase, and undergoes…",
  "key_points": [],
  "editors_take": null,
  "illustration": null,
  "coverage": {
    "outlets": 1,
    "also_reported_by": []
  },
  "ai_generated": true,
  "disclaimer": "Summaries, key points and the editor’s take are written by software from other outlets’ reporting and may contain errors — always check the linked original."
}