{
  "id": 19508454,
  "title": "Within-host evolution of an avirulent Salmonella vaccine strain reveals regulatory tuning of virulence functionality without loss of function",
  "url": "https://urgent.news/2026/11/11/within-host-evolution-of-an-avirulent-salmonella-vaccine-strain",
  "topic": "health",
  "section": "Health & Medicine",
  "published": "2026-11-11T00:00:00.000Z",
  "source": {
    "name": "bioRxiv",
    "slug": "biorxiv",
    "url": "https://www.biorxiv.org/content/10.64898/2026.11.10.765621v1?rss=1"
  },
  "original_language": "en",
  "account": null,
  "summary": "Non-typhoidal Salmonella (NTS) relies on a costly epithelial invasion program encoded in Salmonella pathogenicity island 1 (SPI-1) to overcome microbiota-mediated colonization resistance. Because SPI-1 expression is a cooperative trait in which a minority of invasive SPI-1ON cells benefits the wider bacterial population, inflammatory infection models readily select for permanently avirulent…",
  "key_points": [],
  "editors_take": null,
  "illustration": null,
  "coverage": {
    "outlets": 1,
    "also_reported_by": []
  },
  "ai_generated": true,
  "disclaimer": "Summaries, key points and the editor’s take are written by software from other outlets’ reporting and may contain errors — always check the linked original."
}