{
  "id": 19508452,
  "title": "De novo design of ligases for programmable site-specific protein ubiquitylation",
  "url": "https://urgent.news/2026/11/11/de-novo-design-of-ligases-for-programmable-site-specific-protein",
  "topic": "science",
  "section": "Science",
  "published": "2026-11-11T00:00:00.000Z",
  "source": {
    "name": "bioRxiv",
    "slug": "biorxiv",
    "url": "https://www.biorxiv.org/content/10.64898/2026.11.08.765184v1?rss=1"
  },
  "original_language": "en",
  "account": null,
  "summary": "Protein ubiquitylation regulates numerous cellular processes, but difficulties in generating site-specifically ubiquitylated proteins limit our understanding of individual modification events. In cells, ubiquitylation is mediated by an E1-E2-E3 enzyme cascade, with substrate recognition largely determined by more than 600 human E3 ligases, making it challenging to redirect ubiquitin transfer to a…",
  "key_points": [],
  "editors_take": null,
  "illustration": null,
  "coverage": {
    "outlets": 1,
    "also_reported_by": []
  },
  "ai_generated": true,
  "disclaimer": "Summaries, key points and the editor’s take are written by software from other outlets’ reporting and may contain errors — always check the linked original."
}