{
  "id": 19500517,
  "title": "Integrated exome-transcriptome analysis of a schizophrenia case with an exceptionally low polygenic risk score",
  "url": "https://urgent.news/2026/11/11/integrated-exome-transcriptome-analysis-of-a-schizophrenia-case-with",
  "topic": "science",
  "section": "Science",
  "published": "2026-11-11T00:00:00.000Z",
  "source": {
    "name": "bioRxiv",
    "slug": "biorxiv",
    "url": "https://www.biorxiv.org/content/10.64898/2026.11.09.765277v1?rss=1"
  },
  "original_language": "en",
  "account": null,
  "summary": "Schizophrenia liability reflects both common polygenic variation and rarer variants of larger effect. We investigated a post-mortem schizophrenia case (SZ07) with a schizophrenia polygenic risk score below the first percentile among ancestry-matched cases, asking whether individual-level genomic and transcriptomic analyses could help identify potentially novel schizophrenia-relevant variants. We…",
  "key_points": [],
  "editors_take": null,
  "illustration": null,
  "coverage": {
    "outlets": 1,
    "also_reported_by": []
  },
  "ai_generated": true,
  "disclaimer": "Summaries, key points and the editor’s take are written by software from other outlets’ reporting and may contain errors — always check the linked original."
}