{
  "id": 19500515,
  "title": "Investigating the causal and consequential role of the nuclear encoded mitochondrial genome in Amyotrophic Lateral Sclerosis",
  "url": "https://urgent.news/2026/11/11/investigating-the-causal-and-consequential-role-of-the-nuclear",
  "topic": "science",
  "section": "Science",
  "published": "2026-11-11T00:00:00.000Z",
  "source": {
    "name": "bioRxiv",
    "slug": "biorxiv",
    "url": "https://www.biorxiv.org/content/10.64898/2026.11.10.764216v1?rss=1"
  },
  "original_language": "en",
  "account": null,
  "summary": "Mitochondrial dysfunction is implicated in amyotrophic lateral sclerosis (ALS), but which mitochondrial pathways are involved, and whether their involvement is a cause or a consequence of disease remains unclear. We investigated whether nuclear-encoded mitochondrial gene (NEMG) pathways are enriched for ALS genetic risk, which are dysregulated in ALS tissue, whether pathway activity defines…",
  "key_points": [],
  "editors_take": null,
  "illustration": null,
  "coverage": {
    "outlets": 1,
    "also_reported_by": []
  },
  "ai_generated": true,
  "disclaimer": "Summaries, key points and the editor’s take are written by software from other outlets’ reporting and may contain errors — always check the linked original."
}