{
  "id": 19411962,
  "title": "Pharmaco-genetic evidence of presymptomatic lysosomal dysfunction coupled to detrimental DPR secretion in Drosophila Models of C9orf72-linked ALS/FTD.",
  "url": "https://urgent.news/2026/11/10/pharmaco-genetic-evidence-of-presymptomatic-lysosomal-dysfunction",
  "topic": "health",
  "section": "Health & Medicine",
  "published": "2026-11-10T00:00:00.000Z",
  "source": {
    "name": "bioRxiv",
    "slug": "biorxiv",
    "url": "https://www.biorxiv.org/content/10.64898/2026.11.09.765393v1?rss=1"
  },
  "original_language": "en",
  "account": null,
  "summary": "Hexanucleotide repeat expansions in C9orf72, the most common genetic cause of Amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD), drive neurodegeneration through both loss of gene function and toxic gain-of-function mechanisms, including transcription of repeat RNA and repeat-associated non-AUG (RAN) translation into dipeptide repeat proteins (DPRs). Both disease mechanisms…",
  "key_points": [],
  "editors_take": null,
  "illustration": null,
  "coverage": {
    "outlets": 1,
    "also_reported_by": []
  },
  "ai_generated": true,
  "disclaimer": "Summaries, key points and the editor’s take are written by software from other outlets’ reporting and may contain errors — always check the linked original."
}