{
  "id": 19404274,
  "title": "IL13 critically contributes to the antitumor activity of polyfunctional CD4+ T cells driven by constitutively active Stat5",
  "url": "https://urgent.news/2026/11/10/il13-critically-contributes-to-the-antitumor-activity-of",
  "topic": "science",
  "section": "Science",
  "published": "2026-11-10T00:00:00.000Z",
  "source": {
    "name": "bioRxiv",
    "slug": "biorxiv",
    "url": "https://www.biorxiv.org/content/10.64898/2026.11.09.765236v1?rss=1"
  },
  "original_language": "en",
  "account": null,
  "summary": "The presence of polyfunctional T cells capable of concurrently producing multiple cytokines correlates with favorable clinical outcomes in patients with cancer. We previously reported that overexpression of constitutively active Stat5a (CASTAT5) confers polyfunctionality on tumor-specific CD4 T cells, enabling durable antitumor immunity following adoptive cell therapy. However, the mechanisms…",
  "key_points": [],
  "editors_take": null,
  "illustration": null,
  "coverage": {
    "outlets": 1,
    "also_reported_by": []
  },
  "ai_generated": true,
  "disclaimer": "Summaries, key points and the editor’s take are written by software from other outlets’ reporting and may contain errors — always check the linked original."
}