{
  "id": 19326362,
  "title": "Expression-System Biases Compromise the Functional Assessment of KCNH2 Variants and Clinical Risk Assessment",
  "url": "https://urgent.news/2026/11/10/expression-system-biases-compromise-the-functional-assessment-of",
  "topic": "health",
  "section": "Health & Medicine",
  "published": "2026-11-10T00:00:00.000Z",
  "source": {
    "name": "bioRxiv",
    "slug": "biorxiv",
    "url": "https://www.biorxiv.org/content/10.64898/2026.11.04.764433v1?rss=1"
  },
  "original_language": "en",
  "account": null,
  "summary": "Background: Functional characterization of KCNH2 variants is essential for assessing pathogenicity in long QT syndrome type 2. Because hERG channels assemble as tetramers, the relative expression of wild-type (WT) and variant subunits critically influences channel function and pathogenicity assessment. However, commonly used experimental systems may not reproduce the balanced allelic expression…",
  "key_points": [],
  "editors_take": null,
  "illustration": null,
  "coverage": {
    "outlets": 1,
    "also_reported_by": []
  },
  "ai_generated": true,
  "disclaimer": "Summaries, key points and the editor’s take are written by software from other outlets’ reporting and may contain errors — always check the linked original."
}