{
  "id": 19326356,
  "title": "Replication-stress response shapes Leishmania genome plasticity through non-equivalent RAD9 and HUS1 functions.",
  "url": "https://urgent.news/2026/11/10/replication-stress-response-shapes-leishmania-genome-plasticity",
  "topic": "science",
  "section": "Science",
  "published": "2026-11-10T00:00:00.000Z",
  "source": {
    "name": "bioRxiv",
    "slug": "biorxiv",
    "url": "https://www.biorxiv.org/content/10.64898/2026.11.08.765153v1?rss=1"
  },
  "original_language": "en",
  "account": null,
  "summary": "Genome plasticity, manifested as gene copy-number variation and mosaic aneuploidy, enables adaptation in Leishmania , yet how genome-surveillance pathways shape this variation remains unclear. Here we show that partial depletion of HUS1 or RAD9, subunits of the conserved 9-1-1 checkpoint clamp, produces opposing replication-stress responses and contrasting patterns of genome remodelling in…",
  "key_points": [],
  "editors_take": null,
  "illustration": null,
  "coverage": {
    "outlets": 1,
    "also_reported_by": []
  },
  "ai_generated": true,
  "disclaimer": "Summaries, key points and the editor’s take are written by software from other outlets’ reporting and may contain errors — always check the linked original."
}