{
  "id": 19326354,
  "title": "Lifestyle-mediated shifts in the gut microbiome and host genetics modulate gene expression in intestinal organoids",
  "url": "https://urgent.news/2026/11/10/lifestyle-mediated-shifts-in-the-gut-microbiome-and-host-genetics",
  "topic": "science",
  "section": "Science",
  "published": "2026-11-10T00:00:00.000Z",
  "source": {
    "name": "bioRxiv",
    "slug": "biorxiv",
    "url": "https://www.biorxiv.org/content/10.64898/2026.11.07.765058v1?rss=1"
  },
  "original_language": "en",
  "account": null,
  "summary": "Industrialization-associated shifts in the gut microbiome have been linked to disease, but the mechanisms by which microbial communities influence host gene regulation remain poorly understood. We developed a live microbiome-colonic organoid (colonoid) co-culture system to investigate genotype-dependent host responses to gut microbial community variation. Colonoid 2D monolayers from healthy…",
  "key_points": [],
  "editors_take": null,
  "illustration": null,
  "coverage": {
    "outlets": 1,
    "also_reported_by": []
  },
  "ai_generated": true,
  "disclaimer": "Summaries, key points and the editor’s take are written by software from other outlets’ reporting and may contain errors — always check the linked original."
}