{
  "id": 19231899,
  "title": "BCAS3 regulates WIPI2b via a direct interaction in the ATG16L1-binding cleft",
  "url": "https://urgent.news/2026/11/09/bcas3-regulates-wipi2b-via-a-direct-interaction-in-the-atg16l1",
  "topic": "science",
  "section": "Science",
  "published": "2026-11-09T00:00:00.000Z",
  "source": {
    "name": "bioRxiv",
    "slug": "biorxiv",
    "url": "https://www.biorxiv.org/content/10.64898/2026.11.06.764939v1?rss=1"
  },
  "original_language": "en",
  "account": null,
  "summary": "De novo formation of the phagophore membrane is a fundamental step in autophagy and relies on recruitment of the E3-like ligase complex via an interaction between ATG16L1 and phosphatidylinositol 3-phosphate (PtdIns3P)-effector protein, WIPI2b. Although WIPI2b can directly bind membranes, how its membrane association is regulated is still not fully understood. Here, we describe BCAS3 as a novel…",
  "key_points": [],
  "editors_take": null,
  "illustration": null,
  "coverage": {
    "outlets": 1,
    "also_reported_by": []
  },
  "ai_generated": true,
  "disclaimer": "Summaries, key points and the editor’s take are written by software from other outlets’ reporting and may contain errors — always check the linked original."
}