{
  "id": 19227327,
  "title": "Doxycycline use in early pregnancy associated with higher risk of pregnancy loss",
  "url": "https://urgent.news/2026/11/09/doxycycline-use-in-early-pregnancy-associated-with-higher-risk-of",
  "topic": "science",
  "section": "Science",
  "published": "2026-11-09T22:00:09.000Z",
  "source": {
    "name": "Medical Xpress",
    "slug": "medical-xpress",
    "url": "https://medicalxpress.com/news/2026-11-doxycycline-early-pregnancy-higher-loss.html"
  },
  "original_language": "en",
  "account": "A recent study analyzing insurance claims data from the University of Florida found that women who used doxycycline during early pregnancy for respiratory tract infections or acne were at a higher risk of experiencing pregnancy loss. The retrospective, active-comparator cohort study examined 218,234 pregnancies from women with respiratory tract infections and 6,636 pregnancies from women with acne. Researchers compared women who took doxycycline in the first trimester with similar women who received alternative treatments like amoxicillin and macrolides for respiratory tract infections, and topical clindamycin for acne.\n\nIn the respiratory tract infection group, women taking doxycycline had a higher risk of pregnancy loss compared to those on alternative antibiotics. However, in the acne group, the association between doxycycline use and pregnancy loss was only observed in the commercial claims database, not in the Medicaid database. This suggests that the increased risk for pregnancy loss may be influenced by factors other than the antibiotic itself, such as socioeconomic status or access to healthcare.\n\nThe findings highlight the importance of weighing the potential benefits and risks of doxycycline treatment during early pregnancy. While the study does not establish a definitive causal relationship, it does provide valuable data for clinicians and patients to consider when making decisions about antibiotic use during pregnancy. The study was published in the Annals of Internal Medicine and was conducted by researchers from the University of Florida.",
  "summary": "A retrospective, active-comparator cohort study found that doxycycline use for respiratory tract infections or acne during early pregnancy was associated with an increased risk for pregnancy loss. Given the frequent use of doxycycline by women of childbearing age, these findings underscore the importance of both clinicians and patients weighing the benefits and risks when considering treatment…",
  "key_points": [
    "Women using doxycycline in early pregnancy face higher pregnancy loss risk.",
    "Study compares doxycycline vs. alternative antibiotics for respiratory infections.",
    "Acne group association unclear, may be influenced by socioeconomic factors."
  ],
  "editors_take": null,
  "illustration": null,
  "coverage": {
    "outlets": 1,
    "also_reported_by": []
  },
  "ai_generated": true,
  "disclaimer": "Summaries, key points and the editor’s take are written by software from other outlets’ reporting and may contain errors — always check the linked original."
}