{
  "id": 1915911,
  "title": "Merck, Moderna declare Phase 3 success for personalized mRNA cancer vaccine",
  "url": "https://urgent.news/2026/08/19/merck-moderna-declare-phase-3-success-for-personalized-mrna-cancer",
  "topic": "health",
  "section": "Health & Medicine",
  "published": "2026-08-19T10:45:01.000Z",
  "source": {
    "name": "Endpoints News",
    "slug": "endpoints-news",
    "url": "https://endpoints.news/merck-moderna-declare-phase-3-success-for-personalized-cancer-vaccine/"
  },
  "original_language": "en",
  "account": null,
  "summary": "Merck and Moderna have announced that their personalized mRNA cancer vaccine, intismeran autogene, has succeeded in its first Phase 3 trial. The vaccine was tested in combination with Merck's Keytruda in adjuvant melanoma, where patients' disease had been surgically removed.\n\nThe trial found that the vaccine slowed the return of melanoma and its spread to other parts of the body. According to STAT News, this is the first randomized Phase 3 clinical trial aimed at proving the benefit of so-called \"neoantigen\" vaccines as cancer treatments.\n\nThe results could potentially deliver new hope and longer lives for patients, and may be a testament to the power of mRNA as a platform to develop cancer treatments. Detailed data from the trial has not been released.",
  "key_points": [],
  "editors_take": null,
  "illustration": null,
  "coverage": {
    "outlets": 5,
    "also_reported_by": [
      {
        "outlet": "STAT News",
        "title": "STAT+: Moderna and Merck say mRNA cancer vaccine succeeded in late-stage melanoma trial",
        "url": "https://urgent.news/2026/08/19/stat-moderna-and-merck-say-mrna-cancer-vaccine-succeeded-in-late",
        "published": "2026-08-19T10:45:00.000Z"
      },
      {
        "outlet": "CNBC World",
        "title": "Personalized cancer vaccine from Moderna, Merck shows promise in first late-stage melanoma trial",
        "url": "https://urgent.news/2026/08/19/personalized-cancer-vaccine-from-moderna-merck-shows-promise-in-first",
        "published": "2026-08-19T10:49:31.000Z"
      },
      {
        "outlet": "Quartz",
        "title": "Moderna and Merck's personalized skin cancer vaccine cleared its first large-scale trial",
        "url": "https://urgent.news/2026/08/19/moderna-and-mercks-personalized-skin-cancer-vaccine-cleared-its-first",
        "published": "2026-08-19T11:40:44.000Z"
      },
      {
        "outlet": "Financial Times",
        "title": "Moderna share price doubles on melanoma vaccine trial success",
        "url": "https://urgent.news/2026/08/19/moderna-share-price-doubles-on-melanoma-vaccine-trial-success",
        "published": "2026-08-19T12:08:31.000Z"
      }
    ]
  },
  "ai_generated": true,
  "disclaimer": "Summaries, key points and the editor’s take are written by software from other outlets’ reporting and may contain errors — always check the linked original."
}