{
  "id": 19155398,
  "title": "Projection-specific filtering of delta-theta input by layer 5 neurons in mouse secondary visual cortex",
  "url": "https://urgent.news/2026/11/09/projection-specific-filtering-of-delta-theta-input-by-layer-5-neurons",
  "topic": "science",
  "section": "Science",
  "published": "2026-11-09T00:00:00.000Z",
  "source": {
    "name": "bioRxiv",
    "slug": "biorxiv",
    "url": "https://www.biorxiv.org/content/10.64898/2026.11.06.763938v1?rss=1"
  },
  "original_language": "en",
  "account": "Layer 5 neurons in the mouse secondary visual cortex (V2M) exhibit distinct processing of slow rhythmic input in the delta-theta range. These neurons are divided into two projection classes: extratelencephalic (ET) and intratelencephalic (IT) neurons. IT cells act as low-pass filters, strongly summing small inputs, while ET cells resonate at low frequencies, forming moderate-resonance (ET1, about 3 Hz) and high-resonance (ET2, about 5 Hz) subgroups.\n\nWith small inputs, IT cells exhibit strong summation, acting as low-pass filters. Conversely, ET cells exhibit resonance at low frequencies, with ET1 resonating at around 3 Hz and ET2 at around 5 Hz. With large inputs, ET cells amplify depolarization more than hyperpolarization, maintaining similar resonance frequencies.\n\nWhen stimulated by a 4 Hz sinusoid at threshold, all classes of cells fire at a similar phase and maintain this phase across cycles. In awake mice, visual stimulation increases deep-layer local field potential (LFP) power across a band of frequencies from 1 to 6 Hz, encompassing the mean ET1 and ET2 resonance frequencies.\n\nThus, while the two output classes of layer 5 in V2M process slow rhythmic input differently, once firing, they show no detectable difference in spike timing.",
  "summary": "Delta- and theta-band oscillations are thought to coordinate cortical activity and to convey top-down signals, but how the different output neurons of a cortical area transform such rhythmic input is less well understood. Layer 5 contains two projection classes, extratelencephalic (ET) and intratelencephalic (IT) neurons, which carry different information to different targets. Here we asked…",
  "key_points": [],
  "editors_take": null,
  "illustration": null,
  "coverage": {
    "outlets": 1,
    "also_reported_by": []
  },
  "ai_generated": true,
  "disclaimer": "Summaries, key points and the editor’s take are written by software from other outlets’ reporting and may contain errors — always check the linked original."
}