{
  "id": 18735789,
  "title": "Sequential pathways preserve kinetochore integrity in meiosis",
  "url": "https://urgent.news/2026/11/07/sequential-pathways-preserve-kinetochore-integrity-in-meiosis",
  "topic": "science",
  "section": "Science",
  "published": "2026-11-07T00:00:00.000Z",
  "source": {
    "name": "bioRxiv",
    "slug": "biorxiv",
    "url": "https://www.biorxiv.org/content/10.64898/2026.11.05.764291v1?rss=1"
  },
  "original_language": "en",
  "account": "The study reveals three separate pathways that maintain the integrity of kinetochores, the protein structures that link chromosomes to spindle fibers, during meiosis in budding yeast. These pathways involve the Ctf19 complex, Mif2 bound to CENP-C, and the binding of Okp1 to CENP-Q and Ame1 to CENP-U. While these connections overlap during mitosis, they all play a crucial role during meiosis, with specific timing requirements. The Ctf19cCCAN and Mif2CENP-C-dependent pathways help preserve kinetochore integrity from the start of meiosis, while the Cse4CENP-A-Okp1CENP-Q-Ame1CENP-U binding becomes vital during prophase and the subsequent meiotic divisions. The research also shows that Ipl1Aurora B, an enzyme, works to keep kinetochore integrity intact, independent of the Ctf19cCCAN pathway. Furthermore, the study identifies an outer kinetochore-associated pool of Ipl1Aurora B, suggesting its role in maintaining kinetochore stability. Interestingly, mutations in Cse4CENP-A that mimic Ipl1Aurora B's action, restoring kinetochore integrity in the absence of Ipl1Aurora B depletion, actually worsen defects in cells missing the Ctf19cCCAN pathway. These findings suggest that Ipl1Aurora B might regulate the utilization of alternative kinetochores connections, adapting to the evolving needs of meiosis.",
  "summary": "Kinetochores connect chromosomes to spindle microtubules, but how their integrity is maintained as they are remodelled during meiosis remains poorly understood. Here, we identify three distinct pathways linking centromeric chromatin to the outer kinetochore in budding yeast, mediated by the Ctf19 complex (Ctf19cCCAN), Mif2CENP-C and binding of Okp1CENP-Q-Ame1CENP-U to the Cse4CENP-A essential…",
  "key_points": [],
  "editors_take": null,
  "illustration": null,
  "coverage": {
    "outlets": 1,
    "also_reported_by": []
  },
  "ai_generated": true,
  "disclaimer": "Summaries, key points and the editor’s take are written by software from other outlets’ reporting and may contain errors — always check the linked original."
}