{
  "id": 1855577,
  "title": "Dissociation kinetics and avidity gate SARS-CoV-2 neutralization by HR2 stem helix antibodies",
  "url": "https://urgent.news/2026/08/18/dissociation-kinetics-and-avidity-gate-sars-cov-2-neutralization-by",
  "topic": "science",
  "section": "Science",
  "published": "2026-08-18T00:00:00.000Z",
  "source": {
    "name": "bioRxiv",
    "slug": "biorxiv",
    "url": "https://www.biorxiv.org/content/10.64898/2026.08.17.745160v1?rss=1"
  },
  "original_language": "en",
  "account": null,
  "summary": "SARS-CoV-2 evolution has reduced the efficacy of clinical monoclonal antibodies, underscoring the need for therapeutics targeting conserved viral regions. The Spike (S) heptad repeat 2 (HR2) stem helix is highly conserved across SARS-CoV-2 variants and related betacoronaviruses. Although antibodies to this region can neutralize infection, their natural occurrence and evolution remain poorly…",
  "key_points": [],
  "editors_take": null,
  "illustration": null,
  "coverage": {
    "outlets": 1,
    "also_reported_by": []
  },
  "ai_generated": true,
  "disclaimer": "Summaries, key points and the editor’s take are written by software from other outlets’ reporting and may contain errors — always check the linked original."
}