{
  "id": 18528890,
  "title": "Crigler-Najjar syndrome: Gene therapy maintains its efficacy four years after treatment",
  "url": "https://urgent.news/2026/11/06/crigler-najjar-syndrome-gene-therapy-maintains-its-efficacy-four",
  "topic": "health",
  "section": "Health & Medicine",
  "published": "2026-11-06T16:20:06.000Z",
  "source": {
    "name": "Medical Xpress",
    "slug": "medical-xpress",
    "url": "https://medicalxpress.com/news/2026-11-crigler-najjar-syndrome-gene-therapy.html"
  },
  "original_language": "en",
  "account": null,
  "summary": "The New England Journal of Medicine has published a study on the long-term efficacy of AAV8-mediated gene therapy (GNT0003) in patients with Crigler-Najjar syndrome, an extremely rare congenital liver disorder affecting approximately 500 people in Europe. It is caused by a deficiency of UGT1A1, an enzyme required for bilirubin metabolism. The accumulation of this substance can lead to…",
  "key_points": [],
  "editors_take": null,
  "illustration": null,
  "coverage": {
    "outlets": 1,
    "also_reported_by": []
  },
  "ai_generated": true,
  "disclaimer": "Summaries, key points and the editor’s take are written by software from other outlets’ reporting and may contain errors — always check the linked original."
}