{
  "id": 18308717,
  "title": "Live attenuated YFV-17D vaccine induces robust B and T cell immunity in vaccine-draining lymph nodes",
  "url": "https://urgent.news/2026/11/05/live-attenuated-yfv-17d-vaccine-induces-robust-b-and-t-cell-immunity",
  "topic": "science",
  "section": "Science",
  "published": "2026-11-05T00:00:00.000Z",
  "source": {
    "name": "bioRxiv",
    "slug": "biorxiv",
    "url": "https://www.biorxiv.org/content/10.64898/2026.11.04.764404v1?rss=1"
  },
  "original_language": "en",
  "account": "The yellow fever virus-17D (YFV-17D) vaccine is renowned for its high efficacy, primarily due to the robust immune response it triggers. Understanding the mechanisms behind the long-lasting antibody protection provided by YFV-17D has been a focus of recent research. In a study examining immune dynamics after primary immunization with YFV-17D, researchers utilized fine needle biopsy (FNB) to identify strong T and B lymphocyte reactions within the draining lymph nodes (LNs). These findings suggest that the YFV-17D vaccine fosters the maturation of antibodies targeting the viral envelope (E).\n\nInitially, the antibody responses were predominantly IgM, followed by a gradual increase in E-specific memory B cells and anti-viral IgG over subsequent months. The B cells within the lymph nodes displayed diversified specificity for the envelope protein, contributing to both the binding and neutralising potency of the antibodies. While circulating vaccine-specific CD4+ T cells peaked approximately two weeks post-vaccination, related GC and IL-10+ T follicular helper populations continued to accumulate in the lymph nodes over time.\n\nComparative analysis of transcriptional datasets from YFV-17D, SARS-CoV-2 mRNA/LNP, and seasonal influenza vaccinations revealed a conserved germinal centre (GC) program involving similar B and T lymphocyte subpopulations. The results indicate that while YFV-17D induces a robust GC activity, this characteristic is not unique to this vaccine. The durable protection against the yellow fever virus may be attributed to the host's immune system's ability to withstand the virus, effectively preventing infection.",
  "summary": "The yellow fever virus-17D (YFV-17D) vaccine is widely regarded as one of the most effective vaccines in existence, with protection linked to robust elicitation of neutralising antibodies1. The features of the germinal centre (GC) reaction driving this durable and potent antibody responses remain unclear. Here we examined immune dynamics in blood and lymph nodes (LNs) after primary YFV-17D…",
  "key_points": [],
  "editors_take": null,
  "illustration": null,
  "coverage": {
    "outlets": 1,
    "also_reported_by": []
  },
  "ai_generated": true,
  "disclaimer": "Summaries, key points and the editor’s take are written by software from other outlets’ reporting and may contain errors — always check the linked original."
}