{
  "id": 18177746,
  "title": "High-fat diet promotes exhaustion-associated T-cell remodeling across vascular and lymphoid tissues in atherosclerosis-prone mice",
  "url": "https://urgent.news/2026/11/04/high-fat-diet-promotes-exhaustion-associated-t-cell-remodeling-across",
  "topic": "science",
  "section": "Science",
  "published": "2026-11-04T00:00:00.000Z",
  "source": {
    "name": "bioRxiv",
    "slug": "biorxiv",
    "url": "https://www.biorxiv.org/content/10.64898/2026.11.03.763491v1?rss=1"
  },
  "original_language": "en",
  "account": "A 12-week study on mice fed either a vegetarian diet or a high-fat diet revealed that the latter led to increased exhaustion-associated T-cell states in various tissues. At 24 weeks, these exhaustion-associated cells made up 15.7% of the total T-cell population in mice on high-fat diet, compared to 10.6% in mice on a vegetarian diet. Restoring the diet to a vegetarian one for 12 weeks brought the exhaustion-associated cell proportion back to 10.6%. However, some transcriptional changes remained in different tissues after this dietary reversal. Aortic macrophages in the high-fat diet mice showed signs of inflammation and antigen presentation, along with increased communication with T cells. The aortic T-cells showed increased activation and clonal expansion, with the size of these clonotypes correlating with the exhaustion score (Spearman correlation coefficient = 0.57, p = 0.029). These findings suggest that a high-fat diet can leave a long-lasting impact on the adaptive immune system in multiple organs during the development of atherosclerosis.",
  "summary": "Background: Atherosclerosis is a chronic inflammatory disease driven by lipid accumulation and immune dysregulation. How chronic dietary lipid exposure reshapes T-cell states across vascular and lymphoid tissues, and whether these changes resolve after dietary normalization, remains incompletely defined. This study examined diet-associated T-cell remodeling and the contribution of…",
  "key_points": [],
  "editors_take": null,
  "illustration": null,
  "coverage": {
    "outlets": 1,
    "also_reported_by": []
  },
  "ai_generated": true,
  "disclaimer": "Summaries, key points and the editor’s take are written by software from other outlets’ reporting and may contain errors — always check the linked original."
}