{
  "id": 18177737,
  "title": "A Bias Correction Method for Substructure Estimation with Small Reference Sample Sizes",
  "url": "https://urgent.news/2026/11/04/a-bias-correction-method-for-substructure-estimation-with-small",
  "topic": "science",
  "section": "Science",
  "published": "2026-11-04T00:00:00.000Z",
  "source": {
    "name": "bioRxiv",
    "slug": "biorxiv",
    "url": "https://www.biorxiv.org/content/10.64898/2026.11.04.763213v1?rss=1"
  },
  "original_language": "en",
  "account": null,
  "summary": "Reference data are important for accurate estimation of population substructure, yet sufficiently large reference samples are often unavailable for some populations. This limitation is especially important for methods that estimate population substructure from genetic summary data using reference allele frequencies derived from reference samples, such as Summix2. Here, we systematically evaluated…",
  "key_points": [],
  "editors_take": null,
  "illustration": null,
  "coverage": {
    "outlets": 1,
    "also_reported_by": []
  },
  "ai_generated": true,
  "disclaimer": "Summaries, key points and the editor’s take are written by software from other outlets’ reporting and may contain errors — always check the linked original."
}