{
  "id": 18100366,
  "title": "Bicarbonate-free pH neutralization resensitizes ovarian cancer to chemotherapy and is tracked by 3T CEST MRI",
  "url": "https://urgent.news/2026/11/04/bicarbonate-free-ph-neutralization-resensitizes-ovarian-cancer-to",
  "topic": "health",
  "section": "Health & Medicine",
  "published": "2026-11-04T00:00:00.000Z",
  "source": {
    "name": "bioRxiv",
    "slug": "biorxiv",
    "url": "https://www.biorxiv.org/content/10.64898/2026.11.03.763942v1?rss=1"
  },
  "original_language": "en",
  "account": null,
  "summary": "Ovarian tumors that initially respond to platinum-taxane chemotherapy often relapse as chemoresistant disease. The acidic tumor microenvironment is a well-known but under-exploited driver of this resistance, and neutralization strategies such as oral bicarbonate have not translated. Here we show that inhibiting specific tumor pH regulators at noncytotoxic doses relieves acidosis and restores…",
  "key_points": [],
  "editors_take": null,
  "illustration": null,
  "coverage": {
    "outlets": 1,
    "also_reported_by": []
  },
  "ai_generated": true,
  "disclaimer": "Summaries, key points and the editor’s take are written by software from other outlets’ reporting and may contain errors — always check the linked original."
}