{
  "id": 180960,
  "title": "Sources of Variability in Normative Cerebral FDG-PET imaging",
  "url": "https://urgent.news/2026/08/05/sources-of-variability-in-normative-cerebral-fdg-pet-imaging",
  "topic": "science",
  "section": "Science",
  "published": "2026-08-05T00:00:00.000Z",
  "source": {
    "name": "bioRxiv",
    "slug": "biorxiv",
    "url": "https://www.biorxiv.org/content/10.64898/2026.07.30.741623v1?rss=1"
  },
  "original_language": "en",
  "account": "The variability in normative cerebral FDG-PET imaging is influenced by several factors, including scanner manufacturer, reference region, age, and sex. A study analyzed the impact of these variables on regional [18F]FDG uptake in cognitively normal adults from the Alzheimer's Disease Neuroimaging Initiative (ADNI).\n\nThe research utilized three reference regions - whole cerebellum, pons, and cortical gray matter - to calculate regional SUVr values, which were then converted to Z-scores. Linear regression models were employed to estimate standardized regression coefficients (beta), and 10-fold cross-validation was performed to determine the predictive contribution of each covariate.\n\nResults showed that scanner manufacturer had a significant impact, with Siemens systems yielding higher Z-scores compared to GE and Philips scanners. The difference in Z-scores in specific regions, such as frontal and medial temporal areas, approached one standard deviation. Age also showed region-specific associations, with the strongest biological predictor in cross-validation (R2 approximately 0.11), particularly affecting subcortical nuclei, medial temporal structures, and the posterior cingulate cortex. Sex effects, on the other hand, were found to be negligible (R2 approximately 0).",
  "summary": "Purpose: Quantitative interpretation of brain [18F]FDG-PET increasingly relies on comparisons with normative datasets. However, normative values may be influenced by technical and biological factors, limiting their generalizability. We investigated the effects of scanner manufacturer, reference region, age, and sex on regional [18F]FDG uptake in cognitively normal (CN) adults and generated…",
  "key_points": [],
  "editors_take": null,
  "illustration": null,
  "coverage": {
    "outlets": 1,
    "also_reported_by": []
  },
  "ai_generated": true,
  "disclaimer": "Summaries, key points and the editor’s take are written by software from other outlets’ reporting and may contain errors — always check the linked original."
}