{
  "id": 18093021,
  "title": "Conserved synaptic modifications by humanized tau through diverse isoform- and mutation-specific intracellular interactions",
  "url": "https://urgent.news/2026/11/04/conserved-synaptic-modifications-by-humanized-tau-through-diverse",
  "topic": "science",
  "section": "Science",
  "published": "2026-11-04T00:00:00.000Z",
  "source": {
    "name": "bioRxiv",
    "slug": "biorxiv",
    "url": "https://www.biorxiv.org/content/10.64898/2026.11.03.763730v1?rss=1"
  },
  "original_language": "en",
  "account": null,
  "summary": "Mutations in the microtubule-binding protein tau are considered causal for a diverse group of neurodegenerative diseases collectively referred to as primary tauopathies. Specific tauopathies are associated with different mutations, distinct tau isoforms, manifest in unique cellular and circuit-wide patterns of degeneration, and present with specific clinical symptoms and trajectories. The…",
  "key_points": [],
  "editors_take": null,
  "illustration": null,
  "coverage": {
    "outlets": 1,
    "also_reported_by": []
  },
  "ai_generated": true,
  "disclaimer": "Summaries, key points and the editor’s take are written by software from other outlets’ reporting and may contain errors — always check the linked original."
}