{
  "id": 18034703,
  "title": "A Preventive Effect of Exercise in a Mouse Model of Essential Tremor",
  "url": "https://urgent.news/2026/11/03/a-preventive-effect-of-exercise-in-a-mouse-model-of-essential-tremor",
  "topic": "science",
  "section": "Science",
  "published": "2026-11-03T00:00:00.000Z",
  "source": {
    "name": "bioRxiv",
    "slug": "biorxiv",
    "url": "https://www.biorxiv.org/content/10.64898/2026.11.02.763708v1?rss=1"
  },
  "original_language": "en",
  "account": "Essential tremor (ET) has seen limited research exploring the benefits of exercise, unlike other neurodegenerative disorders. This study investigates how two forms of exercise - high-intensity interval training (HIIT) and resistance training (RT) - affect mice with ET-like symptoms caused by harmaline injections. The researchers used a repeated-measures design, dividing the mice into three groups: one underwent HIIT, another engaged in RT, and the third served as a sedentary control.\n\nThroughout the study, each group received injections before and after the intervention period. The team measured tremor kinetics using accelerometry, analyzing power within the 8-14 and 14-29 Hz frequency bands. Additionally, they conducted high-speed video analysis to assess tremor kinematics, providing further validation.\n\nThe researchers also examined potential signaling molecules released during exercise, specifically focusing on blood lactate and Brain-Derived Neurotrophic Factor (BDNF) levels in each group. The results revealed a significant decrease in power within the 8-14 Hz band for the HIIT group, alongside an increase in the 14-29 Hz band. These changes were not observed in the RT or SED groups. Furthermore, the HIIT group experienced a shift in BDNF concentration.\n\nThe findings suggest that the HIIT protocol may have helped the mice shift tremor frequency to higher bands, offering functional resistance against harmaline-induced tremor. This study supports high-intensity aerobic physical exercise as a potential therapeutic or preventive intervention for ET, with implications for future human studies.",
  "summary": "The effects of exercise have not been widely studied for potential benefits in essential tremor (ET), while this has been growing for other neurodegenerative disorders. This study examines the effects of two types of exercise [high-intensity interval training (HIIT) and resistance training (RT)] on mice that were subjected to harmaline injections to trigger tremor. We employed a repeated-measures…",
  "key_points": [],
  "editors_take": null,
  "illustration": null,
  "coverage": {
    "outlets": 1,
    "also_reported_by": []
  },
  "ai_generated": true,
  "disclaimer": "Summaries, key points and the editor’s take are written by software from other outlets’ reporting and may contain errors — always check the linked original."
}