{
  "id": 18034701,
  "title": "Transcriptomic Analysis of Innate Immune Responses to Toxoplasma gondii in Bat Cells",
  "url": "https://urgent.news/2026/11/03/transcriptomic-analysis-of-innate-immune-responses-to-toxoplasma",
  "topic": "science",
  "section": "Science",
  "published": "2026-11-03T00:00:00.000Z",
  "source": {
    "name": "bioRxiv",
    "slug": "biorxiv",
    "url": "https://www.biorxiv.org/content/10.64898/2026.10.31.763326v1?rss=1"
  },
  "original_language": "en",
  "account": "Bats display an exceptional ability to resist various viral infections, which is linked to unique adaptations in their innate immune and inflammatory systems. The extent to which these adaptations influence the response to non-viral intracellular pathogens remains unclear. The study examined the relationship between the protozoan parasite Toxoplasma gondii and epithelial cell lines from the black flying fox (Pteropus alecto). Results indicated that both strains of T. gondii were able to invade and reproduce within bat cells, showing a high susceptibility to infection. However, the initial response of host cells to the parasite was found to be limited despite the parasite's continued replication inside the cells. A significant transcriptional reaction only became evident at later stages of infection, aligning with widespread parasite replication and cell damage. This reaction was linked to alterations in genes related to inflammatory signaling, metabolic changes, and tissue restructuring. The study concludes that there exists an atypical association between bat cells and this intracellular protozoan pathogen, marked by effective parasite replication and a significant delay in the activation of host transcriptional activity. The findings suggest that the regulation of cellular responses to intracellular infections might not be exclusive to viral pathogens, but could be a more general characteristic of bat immune systems.",
  "summary": "Bats exhibit remarkable tolerance to numerous viral infections, a phenotype associated with distinctive adaptations in innate immune and inflammatory pathways. Whether these adaptations also shape responses to nonviral intracellular pathogens remains poorly understood. Here, we investigated the interaction between the protozoan parasite Toxoplasma gondii and epithelial cell lines derived from the…",
  "key_points": [],
  "editors_take": null,
  "illustration": null,
  "coverage": {
    "outlets": 1,
    "also_reported_by": []
  },
  "ai_generated": true,
  "disclaimer": "Summaries, key points and the editor’s take are written by software from other outlets’ reporting and may contain errors — always check the linked original."
}