{
  "id": 18034691,
  "title": "Resonant Recognition Model analysis of cGAS: conserved spectral frequencies and a divergent naked mole-rat phase signature",
  "url": "https://urgent.news/2026/11/03/resonant-recognition-model-analysis-of-cgas-conserved-spectral",
  "topic": "science",
  "section": "Science",
  "published": "2026-11-03T00:00:00.000Z",
  "source": {
    "name": "bioRxiv",
    "slug": "biorxiv",
    "url": "https://www.biorxiv.org/content/10.64898/2026.10.30.762874v1?rss=1"
  },
  "original_language": "en",
  "account": "Research on the cyclic GMP-AMP synthase (cGAS) protein has unveiled intriguing insights into its diverse functions across different species. In humans, cGAS acts as a cytosolic DNA sensor, yet in the naked mole-rat (NMR), it transitions to promote homologous recombination (HR) via a FANCI-RAD50-dependent pathway. This functional reversal is attributed to four key changes in the protein's C-terminal sequence.\n\nTo delve deeper into the molecular underpinnings of this divergence, scientists employed the Resonant Recognition Model (RRM). This model was applied to cGAS sequences from fourteen different mammals and FANCI sequences from eight species. By converting these genetic sequences into numerical series using EIIP values, researchers then applied a discrete Fourier transform to analyze the resulting spectral features.\n\nThrough point-wise multiplication of individual power spectra, consensus spectra were generated. These spectra revealed four prominent peaks in the cGAS spectrum: frequencies 0.0392, 0.0765, 0.2539, and 0.4229, with the latter being the most dominant. Remarkably, three peaks in the FANCI spectrum (0.04138, 0.2479, 0.4332) were found to be closely aligned with cGAS peaks. Interestingly, when the cGAS and FANCI spectra were combined, the consensus spectrum retained significant peaks at 0.2539 and 0.04077.\n\nA key finding from this spectral analysis was the correlation between the spectral amplitude at frequency 0.2539 and various physiological traits. Specifically, this frequency showed a strong correlation (r = 0.647) with an organism's body mass, suggesting a potential link between cGAS's spectral signature and its physical characteristics. This correlation was statistically significant (p value less than 0.05), indicating a meaningful association.",
  "summary": "Background: Cyclic GMP-AMP synthase (cGAS) is a cytosolic DNA sensor with additional noncanonical nuclear functions, including suppression of homologous recombination (HR) in humans. In the naked mole-rat (NMR), cGAS instead promotes HR through a FANCI-RAD50-dependent mechanism, a functional reversal attributed to four C-terminal amino acid substitutions. Whether such functional divergence is…",
  "key_points": [],
  "editors_take": null,
  "illustration": null,
  "coverage": {
    "outlets": 1,
    "also_reported_by": []
  },
  "ai_generated": true,
  "disclaimer": "Summaries, key points and the editor’s take are written by software from other outlets’ reporting and may contain errors — always check the linked original."
}