{
  "id": 18004359,
  "title": "ssGSEA3.0: Feature-Level Bootstrap Resampling for Robust Assessment of Statistical Significance",
  "url": "https://urgent.news/2026/11/03/ssgsea3-0-feature-level-bootstrap-resampling-for-robust-assessment-of",
  "topic": "science",
  "section": "Science",
  "published": "2026-11-03T00:00:00.000Z",
  "source": {
    "name": "bioRxiv",
    "slug": "biorxiv",
    "url": "https://www.biorxiv.org/content/10.64898/2026.10.28.762524v1?rss=1"
  },
  "original_language": "en",
  "account": null,
  "summary": "Motivation Single-sample Gene/Post-Translational Modification Set Enrichment Analysis (ssGSEA/PTM-SEA) methods assess pathway or signature activity per sample using permutation-based significance testing. ssGSEA2.0's weighted scoring (ssGSEA2.0-orig) uses a correlation-vector reordering that inflates false positives at nonzero weight; directly fixing this (ssGSEA2.0-fixed) restores…",
  "key_points": [],
  "editors_take": null,
  "illustration": null,
  "coverage": {
    "outlets": 1,
    "also_reported_by": []
  },
  "ai_generated": true,
  "disclaimer": "Summaries, key points and the editor’s take are written by software from other outlets’ reporting and may contain errors — always check the linked original."
}