{
  "id": 18004356,
  "title": "Protein Pocket Coengagement Prioritizes Drug-Drug Interactions",
  "url": "https://urgent.news/2026/11/03/protein-pocket-coengagement-prioritizes-drug-drug-interactions",
  "topic": "science",
  "section": "Science",
  "published": "2026-11-03T00:00:00.000Z",
  "source": {
    "name": "bioRxiv",
    "slug": "biorxiv",
    "url": "https://www.biorxiv.org/content/10.64898/2026.10.28.762582v1?rss=1"
  },
  "original_language": "en",
  "account": null,
  "summary": "Drug-drug interactions (DDIs) are largely catalogued empirically, with limited structural explanation of why two drugs interact. We asked whether a purely structural mechanism - competing or cooperating engagement of the same protein pocket - is sufficient to recover documented DDIs without any training on clinical interaction labels. Using composite protein multiple-ligand (COLIG) assignments,…",
  "key_points": [],
  "editors_take": null,
  "illustration": null,
  "coverage": {
    "outlets": 1,
    "also_reported_by": []
  },
  "ai_generated": true,
  "disclaimer": "Summaries, key points and the editor’s take are written by software from other outlets’ reporting and may contain errors — always check the linked original."
}