{
  "id": 17980880,
  "title": "Apolipoprotein E4 Exacerbates Aβ Oligomer-Induced Synaptotoxicity through Promoting Autophagic Degradation of Glutathione Peroxidase 4",
  "url": "https://urgent.news/2026/11/03/apolipoprotein-e4-exacerbates-a-oligomer-induced-synaptotoxicity",
  "topic": "science",
  "section": "Science",
  "published": "2026-11-03T00:00:00.000Z",
  "source": {
    "name": "bioRxiv",
    "slug": "biorxiv",
    "url": "https://www.biorxiv.org/content/10.64898/2026.11.01.763365v1?rss=1"
  },
  "original_language": "en",
  "account": null,
  "summary": "Extensive synaptic loss and progressive neurodegeneration are defining pathological hallmarks of Alzheimer's disease (AD), primarily driven by soluble A{beta} oligomers and neurofibrillary tangles. The apolipoprotein E4 (APOE4) isoform further aggravates these pathological cascades, yet the precise molecular mechanisms underlying AD pathogenesis remain poorly elucidated. Store-operated calcium…",
  "key_points": [],
  "editors_take": null,
  "illustration": null,
  "coverage": {
    "outlets": 1,
    "also_reported_by": []
  },
  "ai_generated": true,
  "disclaimer": "Summaries, key points and the editor’s take are written by software from other outlets’ reporting and may contain errors — always check the linked original."
}