{
  "id": 17980877,
  "title": "HOT1 functions as a homodimer to promote ALT-permissive chromatin",
  "url": "https://urgent.news/2026/11/03/hot1-functions-as-a-homodimer-to-promote-alt-permissive-chromatin",
  "topic": "science",
  "section": "Science",
  "published": "2026-11-03T00:00:00.000Z",
  "source": {
    "name": "bioRxiv",
    "slug": "biorxiv",
    "url": "https://www.biorxiv.org/content/10.64898/2026.11.02.763659v1?rss=1"
  },
  "original_language": "en",
  "account": null,
  "summary": "Telomere homeostasis is a tightly regulated and dynamic process sustained by a network of proteins that organize telomeric chromatin and safeguard chromosome stability. In ALT-positive cells, telomere maintenance relies on recombination-based mechanisms and is modulated by local chromatin states and epigenetic regulation. Here, we show that the telomeric binding protein HOT1 (HMBOX1) requires…",
  "key_points": [],
  "editors_take": null,
  "illustration": null,
  "coverage": {
    "outlets": 1,
    "also_reported_by": []
  },
  "ai_generated": true,
  "disclaimer": "Summaries, key points and the editor’s take are written by software from other outlets’ reporting and may contain errors — always check the linked original."
}