{
  "id": 17957621,
  "title": "Res ipSAE adhuc loquuntur: What the directionality of predicted aligned error in cofolding models can tell us about scoring diverse molecular complexes",
  "url": "https://urgent.news/2026/11/03/res-ipsae-adhuc-loquuntur-what-the-directionality-of-predicted",
  "topic": "science",
  "section": "Science",
  "published": "2026-11-03T00:00:00.000Z",
  "source": {
    "name": "bioRxiv",
    "slug": "biorxiv",
    "url": "https://www.biorxiv.org/content/10.64898/2026.11.02.763449v1?rss=1"
  },
  "original_language": "en",
  "account": null,
  "summary": "AlphaFold 3 (AF3) and Boltz-2 estimate confidence in predicted biomolecular complexes using the interface predicted template modeling (ipTM) score, which is derived from probability distributions of predicted aligned errors (PAEs) between molecular tokens. These errors are directional: the predicted position of tokens in one molecule is evaluated relative to coordinate frames defined by tokens in…",
  "key_points": [],
  "editors_take": null,
  "illustration": null,
  "coverage": {
    "outlets": 1,
    "also_reported_by": []
  },
  "ai_generated": true,
  "disclaimer": "Summaries, key points and the editor’s take are written by software from other outlets’ reporting and may contain errors — always check the linked original."
}