{
  "id": 17957618,
  "title": "An LRH-1 agonist reverses hepatic metabolic dysfunction in obesity",
  "url": "https://urgent.news/2026/11/03/an-lrh-1-agonist-reverses-hepatic-metabolic-dysfunction-in-obesity",
  "topic": "health",
  "section": "Health & Medicine",
  "published": "2026-11-03T00:00:00.000Z",
  "source": {
    "name": "bioRxiv",
    "slug": "biorxiv",
    "url": "https://www.biorxiv.org/content/10.64898/2026.10.28.761933v1?rss=1"
  },
  "original_language": "en",
  "account": null,
  "summary": "Liver receptor homolog-1 (LRH-1; NR5A2) is a nuclear receptor that controls metabolic gene programs important for liver health. Here, we address two challenges with dissecting ligand-driven LRH-1 metabolism in vivo. First, we generate ME610, a potent LRH-1 agonist with favorable pharmacokinetic properties. Second, we engineer Nr5a2humLBD mice, edited to recapitulate the ligand response of the…",
  "key_points": [],
  "editors_take": null,
  "illustration": null,
  "coverage": {
    "outlets": 1,
    "also_reported_by": []
  },
  "ai_generated": true,
  "disclaimer": "Summaries, key points and the editor’s take are written by software from other outlets’ reporting and may contain errors — always check the linked original."
}