{
  "id": 17942581,
  "title": "An Improved Manufacturing Method for Infusible Extracellular Matrix Materials to Enable Efficient Scale-Up, Improved Efficacy, and Clinical Translation",
  "url": "https://urgent.news/2026/11/02/an-improved-manufacturing-method-for-infusible-extracellular-matrix",
  "topic": "science",
  "section": "Science",
  "published": "2026-11-02T00:00:00.000Z",
  "source": {
    "name": "bioRxiv",
    "slug": "biorxiv",
    "url": "https://www.biorxiv.org/content/10.64898/2026.10.29.762959v1?rss=1"
  },
  "original_language": "en",
  "account": "Decellularized extracellular matrix (ECM) materials are widely used in tissue engineering and regenerative medicine due to their bioactive properties. To address the challenges in manufacturing infusible extracellular matrix (iECM) materials, a new method utilizing depth filtration and tangential flow filtration (DF-TFF) was developed. This method aims to improve manufacturing efficiency, increase iECM concentration, and enhance clinical translation.\n\nThe researchers compared iECM made with DF-TFF to that made with conventional centrifugation, dialysis, and filtration (C-D-F) methods. The results showed that iECM produced using DF-TFF had similar properties and could be produced at higher concentrations. As a result, the researchers demonstrated that DF-TFF could lead to dose-dependent responses in acute myocardial infarction (MI) porcine models and mouse multiple organ dysfunction syndrome (MODS) models.\n\nFurthermore, DF-TFF allowed for the production of iECM from alternative tissue sources, providing flexibility in sourcing materials. By implementing this improved manufacturing method, the study highlights the potential for enhanced production time, scalability, compliance with current good manufacturing practices (cGMP), and increased doses of iECM. These advancements pave the way for future clinical applications and additional preclinical studies, ultimately advancing the field of tissue engineering and regenerative medicine.",
  "summary": "Decellularized extracellular matrix (ECM) materials are a popular choice for tissue engineering and regenerative medicine applications due to their multifaceted bioactive capabilities arising from their heterogenous composition. For minimally invasive delivery, infusible ECM (iECM) was developed through fractionation of digested decellularized ECM, allowing the material to be safely delivered…",
  "key_points": [],
  "editors_take": null,
  "illustration": null,
  "coverage": {
    "outlets": 1,
    "also_reported_by": []
  },
  "ai_generated": true,
  "disclaimer": "Summaries, key points and the editor’s take are written by software from other outlets’ reporting and may contain errors — always check the linked original."
}